Regrow Your Hair, Starting Now
 A New Science Now series from New Health & Longevity and Apple Poly LLC

Current Science on TGF-β as a Biochemical Target in Hair Loss

    Regulation of DHT by 5 alpha-reductase inhibitors is a proven method to reduce hair loss, improve follicle performance, and regrow hair in some individuals. It is the accepted mechanism of action of Propecia^®, and the prevailing theory in androgenetic alopecia.

    In the last 13 years, a new theory has emerged that promises a more precise understanding of androgen-sensitive hair loss, and a more selective therapeutic target for intervention. This theory holds that inhibition of DHT is effective partially or primarily because it limits the protein Transforming Growth Factor beta, or TGF-β, in the catagen cascade.

    As a downstream factor in the androgen cascade, TGF-β may prove to be a more effective target than DHT. The growing consensus among leading hair loss researchers is that TGF-β causes premature entry into catagen, and that it may be the primary agent responsible for follicle miniaturization and dysfunction.

    The following papers discuss the relationship between TGF-β and hair follicle dysfunction. Taken together, they present a compelling case that undermines the prevailing theory that DHT "causes" hair loss in AGA. They also suggest that using TGF-β inhibitors may prevent premature entry into catagen, lengthen the anagen phase of hair growth, and prevent miniaturization of androgen-sensitive hair follicles.

Apple procyanidins are proven to strongly and safely inhibit TGF-β directly in the hair follicle.
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